The three new cases were reported from Phek district.
The two patients succumbed to their critical infections on Thursday morning at Gauhati Medical College and Hospital (GMCH), state Health Minister Himanta Biswa Sarma posted on Twitter.
The COVID-19 Common Control Room stated on Wednesday five persons from Senapati district were confirmed as new COVID-19 positive cases in the last 24 hours since Tuesday.
It is expected that the covid care centre at Manipur Trade and Expo Lamboi Khongnangkhong will begin to function within this week.
Necessary preparations are underway with joint efforts from the medical directorate, PWD, PHED and electricity department.